COVID-19 Real-World Evidence Primer

Chapter 4: Examples of COVID-19 Real-World Evidence Studies

Authors: Christina DeFilippo Mack, PhD, MSPH, FISPE1; Michael Mbagwu, MD2; Matthew T Roe, MD, MHS3,4

1IQVIA Real-World Solutions
2Verana Health
3Duke University School of Medicine
4The Duke Clinical Research Institute

This chapter provides select examples of COVID-19 studies that used real-world data (RWD) to generate real-world evidence (RWE) that addresses public health questions during the pandemic. The studies presented include:

  • target trial emulation
  • cohort study
  • case-control study
  • self-control case series
  • drug utilization study
  • diagnostic test evaluation study

Each study summary includes the study name; citation details; study objective; population, intervention, comparison, and outcomes (PICO); data source(s), and study period. For each study, we highlight how authors handled key potential sources of error.