Researchers can use crafting a plan to disseminate RWE research to help identify target audiences, refine messages, and select communication pathways to share findings effectively. The foundation of such a plan is clearly defining and prioritizing the audience or audiences that need to be reached. Audiences should typically include internal groups (i.e., colleagues) as well as external groups, such as the scientific community, decision-makers (e.g., clinicians, policy-makers), and the general public. The latter is a commonly ignored but important audience for the communication of scientific evidence, considering the growing reach of misinformation and distrust in science.